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            ChemicalBook >> CAS DataBase List >>D-Phenylalanine


            CAS No.
            Chemical Name:
            PHENYLALANINE;d-phe;H-D-PHE-OH;D-Phe-OH;(R)-PHENYLALANINE;(R)-2-amino-3-phenylpropanoic acid;NSC 25005;nci-c60195;Endorphenyl;D-Phenylalanin
            Molecular Formula:
            Molecular Weight:
            MOL File:
            MSDS File:

            D-Phenylalanine Properties

            Melting point 273-276 °C(lit.)
            Boiling point 293.03°C (rough estimate)
            alpha 33.5 º (c=2, H2O)
            Density 1.1603 (rough estimate)
            refractive index 34 ° (C=2, H2O)
            storage temp. Store at RT.
            solubility Methanol (Slightly), Water (Slightly)
            form Powder
            pka 2.2(at 25℃)
            color White to off-white
            Water Solubility 27 g/L (20 ºC)
            Merck 14,7271
            BRN 2804068
            Stability Stable. Incompatible with strong oxidizing agents, acids, bases.
            CAS DataBase Reference 673-06-3(CAS DataBase Reference)
            EPA Substance Registry System D-Phenylalanine (673-06-3)


            Risk and Safety Statements

            Hazard Codes  Xi,C
            Risk Statements  34
            Safety Statements  24/25-45-36/37/39-27-26
            WGK Germany  3
            RTECS  AY7533000
            Hazard Note  Irritant
            TSCA  Yes
            HS Code  29224995
            Toxicity TDLo orl-hmn: 500 mg/kg/5W-I:GIT JACTDZ 1(3),124,82
            NFPA 704
            1 0

            D-Phenylalanine price More Price(43)

            Manufacturer Product number Product description CAS number Packaging Price Updated Buy
            Sigma-Aldrich P1751 D-Phenylalanine ≥98% (HPLC) 673-06-3 5g $32.8 2022-05-15 Buy
            Sigma-Aldrich P1751 D-Phenylalanine ≥98% (HPLC) 673-06-3 25g $106 2022-05-15 Buy
            TCI Chemical P0135 D-Phenylalanine >98.0%(T) 673-06-3 5g $20 2022-04-27 Buy
            TCI Chemical P0135 D-Phenylalanine >98.0%(T) 673-06-3 25g $55 2022-04-27 Buy
            Alfa Aesar A10572 D-Phenylalanine, 99% 673-06-3 25g $85.5 2021-12-16 Buy
            Product number Packaging Price Buy
            P1751 5g $32.8 Buy
            P1751 25g $106 Buy
            P0135 5g $20 Buy
            P0135 25g $55 Buy
            A10572 25g $85.5 Buy

            D-Phenylalanine Chemical Properties,Uses,Production


            D-phenylalanine is an inhibitor of enzymes that inactivate enkephalins. Enkephalins are naturally occurring morphine-like peptides that function to reduce pain. By blocking enzymes from degrading enkephalins, D-phenylalanine can reduce pain severity. Phenylalanine is the only amino acid other than methionine in which both isomers, L and D, are readily absorbed. DLPA is 50% D-phenylalanine and 50% L-phenylalanine, making it clinically useful as a neurotransmitter precursor and as a potential pain mediator.
            Phenylalanine is found in three different forms. The natural form, found in food, is also called L-phenylalanine. There’s also a synthetic form, D-phenylalanine, which is very similar to the natural version. Both of these forms come with their own unique benefits, but if you want to get the most out of them, you’ll want to look at the third form: DL-phenylalanine. This form combines both the “L” and “D” forms, creating a supplement with the benefits of both types.

            In vitro

            The binding of D-Phenylalanine to carboxypeptidase A confers anion sensitivity upon the function of the enzyme by breaking the hydrogen bond between the active site base, Glu-270, and the zinc-bound water molecule.

            In vivo

            D-Phenylalanine (500 mg/kg p.o.) produces a small increase in aversive threshold which is not statistically significant and not naloxone reversible. Acetylsalicylic acid (200 mg/kg p.o.) but not zomepirac sodium (200 mg/kg p.o.) in combination with D-phenylalanine (500 mg/kg) produces a small statistically significant increase in aversive threshold.

            Biological Activity

            DL-Phenylalanine (DLPA) is marketed as a nutritional supplement for its purported analgesic and antidepressant activities. DL-Phenylalanine is a mixture of D-phenylalanine and L-phenylalanine. The reputed analgesic activity of DL-phenylalanine may be explained by the possible blockage by D-phenylalanine of enkephalin degradation by the enzyme carboxypeptidase A. The mechanism of DL-phenylalanine's supposed antidepressant activity may be accounted for by the precursor role of L-phenylalanine in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain levels of norepinephrine and dopamine are thought to have an antidepressant effect. D-Phenylalanine is absorbed from the small intestine and transported to the liver via the portal circulation. A small amount of D-phenylalanine appears to be converted to L-phenylalanine. D-Phenylalanine is distributed to the various tissues of the body via the systemic circulation. It appears to cross the blood–brain barrier less efficiently than L-phenylalanine, and so a small amount of an ingested dose of D-phenylalanine is excreted in the urine without penetrating the central nervous system.


            D-phenylalanine (DPA) decreases pain by blocking the enzymes that break down the body's natural painkillers. Clinical studies suggest DPA may inhibit some types of chronic pain.
            Certain amino acids have been found to raise pain thresholds and increase tolerance to pain. One of these, a synthetic amino acid called D-phenylalanine (DPA), decreases pain by blocking the enzymes that break down endorphins and enkephalins, the body's natural pain-killing chemicals. DPA may also produce pain relief by other mechanisms, which are not well understood.
            In animal studies, DPA decreased chronic pain within 15 minutes of administration and the effects lasted up to six days. It also decreased responses to acute pain. These findings have been independently verified in at least five other studies. Clinical studies on humans suggest DPA may inhibit some types of chronic pain, but it has little effect on most types of acute pain.

            Side Effects

            Phenylalanine is found in many protein-containing foods and is “generally recognized as safe” by the Food and Drug Administration (FDA). The amount of this amino acid found in foods should not pose a risk for otherwise healthy individuals. What’s more, few or no side effects are generally observed at supplement doses of 23–45 mg per pound (50–100 mg per kg) of body weight. However, it may be best for pregnant women to avoid taking phenylalanine supplements.


            D-Phenylalanine, also known as D-alpha-Amino-beta-phenylpropionic acid, is a kind of non-proteinogenic amino acid. The biological function of D-phenylalanine remains unclear. However, it has certain anti-depressant, analgesic activities and pharmacological activity at niacin receptor II. The mechanism action of its analgesic activity seems to originate from its inhibition of enkephalin degradation by the carboxypeptidase A. Enkephalins are part of your body’s natural pain relief system. When they are broken down by enkephalinase, this contributes to the sensation of pain. D-Phenylalanine is specifically thought to be beneficial for reducing feelings of chronic pain. D-phenylalanine has been used with mixed results to treat chronic pain, including pain caused by rheumatoid arthritis. The primary use of D-phenylalanine as a health supplement is the relief of discomfort.

            Chemical Properties

            White crystalline powder


            D-Phenylalanine, the stereoisomer of L-Phenylalanine (P319415) has been used in the synthesis of Schaeffer’s acid analogues as important structures in tuberculostatic design. They exhibit the ability to inhibit Mycobacterium tuberculosis type II dehydroquinase.


            ChEBI: D-phenylalanine is the D-enantiomer of phenylalanine. It is a phenylalanine and a D-alpha-amino acid. It is a conjugate base of a D-phenylalaninium. It is a conjugate acid of a D-phenylalaninate. It is an enantiomer of a L-phenylalanine. It is a tautomer of a D-phenylalanine zwitterion.

            General Description

            D-phenylalanine appears as needles or prisms.

            Air & Water Reactions

            Water soluble. Aqueous solutions are weakly acidic.

            Reactivity Profile

            D-alpha-Amino-beta-phenylpropionic acid may be light sensitive. D-alpha-Amino-beta-phenylpropionic acid reacts with strong oxidizing agents, acids and bases. . Act as weak acids in solution.

            Fire Hazard

            Flash point data for D-alpha-Amino-beta-phenylpropionic acid are not available, however D-alpha-Amino-beta-phenylpropionic acid is probably combustible.


            D-Phenylalanine is the synthetic dextro isomer of phenylalanine, an essential amino acid with anti-depressant and analgesic activities. D-Phenylalanine is converted into tyrosine and tyrosine in turn is converted into L-dopa, norepinephrine, and epinephrine, three key neurotransmitters. As a result this agent is associated with elevated levels of the neurotransmitters dopamine and norepinephrine in the brain, which may alleviate symptoms of depression. In addition, as an inhibitor of enkephalinase, which metabolizes endorphins, D-phenylalanine may be used to treat chronic pain through blocking the break down of endorphins (natural pain killers).

            Safety Profile

            Mildly toxic by intraperitoneal route. Human systemic effects by ingestion: nausea, hypermotility, diarrhea. When heated to decomposition it emits toxic fumes of NOx.


            Christianson, D. W., et al. "Binding of D-phenylalanine and D-tyrosine to carboxypeptidase A. " Journal of Biological Chemistry264.22(1989):12849-53.

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            View Lastest Price from D-Phenylalanine manufacturers

            Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
            2022-04-02 D-Phenylalanine
            US $30.00 / KG 1KG 99% 20 Tons Wuhan wingroup Pharmaceutical Co., Ltd
            2022-03-24 D-Phenylalanine
            US $1.00 / g 1g 99% 1ton Henan Guange Biotechnology Co. LTD
            2022-02-25 D-phenylalanine
            US $10.00 / KG 1Kg/Bag 99% 20 Hong Kong Tiansheng New Material Trading Co., Ltd
            • D-Phenylalanine
            • US $30.00 / KG
            • 99%
            • Wuhan wingroup Pharmaceutical Co., Ltd
            • D-phenylalanine
            • US $10.00 / KG
            • 99%
            • Hong Kong Tiansheng New Material Trading Co., Ltd
            D-PHENYLALANINE, >=98% (HPLC) D-beta-Phenyl-alpha-aminopropionic acid d-alpha-aminohydrocinnamic acid D-ALPHA-AMINO-BETA-PHENYL-PROPIONIC ACID D-2-AMINO-3-PHENYLPROPANOIC ACID D(+)-PHENYLALANINE D-PHENYLALANINE RARECHEM AB PP 0687 (R)-2-AMINO-3-PHENYLPROPIONIC ACID D-PHENYLALANINE, 99+% (98% EE/GLC) D-Phenylalanine,>99% D-α-Amino-β-phenylpropionic acid Alanine, phenyl-, D- (8CI) D-a-Amino-b-phenylpropionic acid D-b-Phenylalanine D-Phenylalanine (9CI) NSC 25005 D-Phenylalanin D-Phenglalanine,(R)-(+)-Phenglalanine H-D-PHE-OH D-PHENYLALANINE D-PHENYLALANINE ((R)-PHENYLALANINE) (2R)-2-Amino-3-phenylpropanoic acid (2R)-2-Amino-3-phenylpropionic acid (R)-2-Benzylglycine D-Phenylalanine≥ 99% (Assay) D-PHENYLALANINE extrapure CHR (R)-(+)-Phenylalanine, (R)-2-Amino-3-phenylpropionic acid, D-2-Amino-3-phenylpropanoic acid nci-c60195 D-Phenylalanine,(R)-2-Amino-3-phenylpropionic acid D-Phenylalanine Vetec(TM) reagent grade, >=98% NATEGLINIDE INTERMEDIATES D-Phenyl-d5-alanine-d3 Endorphenyl D-2-Amino-3-phenylpropionic acid D-3-Benzene-2-Amnopropanoic Acid D-α-Aminohydrocinnamic acid D-Phenylalanine, 99%, reagent grade D-Phenylalanine> D-Phenylalanine fandachem D-Phenylalanine USP/EP/BP D-Phenylalanine,0.98 dextro-phenyl alanine D-phenylanaline D-Phe-OH d-phe H-D-PHE-OH (R)-PHENYLALANINE PHENYLALANINE (R)-2-amino-3-phenylpropanoic acid 673-06-3 673-06-9 C6H5CH2CHNH2CO2H Specialty Synthesis Peptide Synthesis Amino Acid Derivatives Amino Acids Biochemistry Amino Acids
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