ChemicalBook >?? ???? >?? ??>???>? ?? ???>????

????

???? ??? ???

?? ??:: 288-32-4

???:: ????

???(??):: ????;1,3-???(1,3-DIAZOLE)????(IMINAZOLE)???(MIAZOLE)???(B)-???(PYRRO(B)-MONAZOLE)1,3-???-2,4-???????(1,3-DIAZA-2,4-CYCLOPENTADIENE)?????(GLYOXALIN)????(IMIDAZOL)????(IMUTEX)1H-????;?????;1,3-???;????;???;?????;????;???(B)-???;1,3-????-2,4-????????;1,3-????;1H-????(9CI);????;????????, N,N'-1,2-????-;????(8CI)

???:: Imidazole

???(??):: 1H-IMIDAZOLE;Imidazol;IMZ;IMD;GLYOXALINE;LMIDAZOLE;IMINAZOLE;GLYOXALIN;Imidazoie;1H-Imidazol

CBNumber:: CB6460617

???:: C3H4N2

??? ??:: 68.08

MOL ??:: 288-32-4.mol

Request For Quotation

?? ?? ?? ?? ?? 862

???? ??

???: 88-91 °C(lit.)

?? ?: 256 °C(lit.)

??: 1.01 g/mL at 20 °C

???: <1 mm Hg ( 20 °C)

???: 1.4801

???: 293 °F

?? ??: Store below +30°C.

???: H₂O: 0.1 M at 20 °C, clear, colorless

??? ??: crystalline

?? ?? (pKa): 6.953(at 25℃)

Specific Gravity: 1.03

??: white

??: Amine like

pH ??: 9.5 - 11

??????(pH): 9.5-11.0 (25℃, 50mg/mL in H2O)

???: 633 g/L (20 ºC)

??: Hygroscopic

?? ??(λmax): λ: 260 nm Amax: 0.10
λ: 280 nm Amax: 0.10

Merck: 14,4912

BRN: 103853

???: Stable. Incompatible with acids, strong oxidizing agents. Protect from moisture.

InChIKey: RAXXELZNTBOGNW-UHFFFAOYSA-N

CAS ??????: 288-32-4(CAS DataBase Reference)

NIST: 1H-Imidazole(288-32-4)

EPA: Imidazole (288-32-4)

?? ? ?? ??
?? ? ???? ?? (GHS)

??? ??	C,Xi,T
?? ???? ??	36/38-63-34-22-20/21/22-61
?????	26-36/37/39-45-22-36-27-53
????(UN No.)	UN 2923 8/PG 3
WGK ??	1
RTECS ??	NI3325000
?? ?? ??	480 °C
TSCA	Yes
?? ??	8
????	III
HS ??	29332990
?? ?? ???	288-32-4(Hazardous Substances Data)
??	LD50 in mice (mg/kg): 610 i.p.; 1880 orally (Nishie)
???? ??	KE-20937

????(GHS):

?? ?:

Danger

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H301	??? ???	?? ?? ?? - ??	?? 3	??	P264, P270, P301+P310, P321, P330,P405, P501
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H314	??? ?? ??? ?? ??? ???	????? ?? ?????	?? 1A, B, C	??	P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H318	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 1	??	P280, P305+P351+P338, P310
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H360	?? ?? ????? ??? ??? ? ??	???? ??	?? 1A, 1B	??
H361	?? ?? ????? ??? ??? ??? ???	???? ??	?? 2	??	P201, P202, P281, P308+P313, P405,P501
H371	??(??, ??? ?? ??? ?? ??? ??)? ??? ??? ? ??(????? ?? ???? ??? ???? ???? ???? ????? ??? ????? ??)	?? ???? ?? - 2? ??	?? 2	??	P260, P264, P270, P309+P311, P405,P501

??????:

P201	?? ? ?? ???? ?????.
P202	?? ?? ?? ??? ?? ???? ??? ???? ???.
P260	??·?·??·???·??·...·????? ???? ???.
P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P270	? ??? ??? ??? ???, ???? ???? ???.
P280	????/???/???/?????? ?????.
P310	?? ????(??)? ??? ????. ???? ?? ????(??)? ??? ????.
P301+P330+P331	???? ?? ?????. ??? ?? ?? ???.
P303+P361+P353	??(?? ????)? ??? ??? ?? ??? ??? ????? ??? ?? ????/?????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P308+P313	?? ?? ??? ???? ???? ??· ??? ????.
P405	???? ?????.
P501	...? ??? / ??? ?? ???.

NFPA 704

	1
3		0

???? C??? ??, ??, ??

??

????? ??????? ????? ???? ??, ?? ??. ?? ???? ??, ?, ???? ? ???. ???? C3H4N2. [??? ?] ?????.

??? ??

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar.The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.

??

Excellent for buffers in the range of pH 6.2-7.8
Imidazole has been used

in the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein.
in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography.
as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cell.

??

ChEBI: An imidazole tautomer which has the migrating hydrogen at position 1.

?? ??

Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.

????

It is less toxic relative to pyrrole and otherfive-membered heterocyclic compounds ofnitrogen. Intraperitoneal administration ofimidazole caused somnolence, muscle contractions,and convulsions in mice. Theoral LD50 value in mice is in the range900 mg/kg.

????

Noncombustible solid.

Purification Methods

Crystallise imidazole from *benzene, CCl4, CH2Cl2, EtOH, pet ether, acetone/pet ether and distilled de-ionized water. Dry it at 40o under vacuum over P2O5. Distil it at low pressure. It is also purified by sublimation or by zone melting. [Snyder et al. Org Synth Coll Vol III 471 1955, Bredereck et al. Chem Ber 97 827 1964, Caswell & Spiro J Am Chem Soc 108 6470 1986.] 15N-imidazole crystallises from *benzene [Scholes et al. J Am Chem Soc 108 1660 1986]. [Beilstein 23 II 34, 23 III/IV 564, 23/4 V 191.]

???? ?? ?? ? ???

???

4,5-?????????? ???? ????? 1H-?????? ????? ??? ?? ???? ?? ?II?? Concentrated sulfuric acid ?? ??? ?? Benzimidazole O-???????

?? ??

2-(1H-IMIDAZOL-1-YL)BENZOIC ACID ??? ????-2-???????? beta-Methyl vinyl phosphate (MAP) ?????????? 2-Bromo-4-nitroimidazole imidazol-2-ylamine sulphate 1-?????? 4-(????-1-?)?? Orazamide 6-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONITRILE 1-(1-2-HYDROXYPHENYL)ETHENYL)-1H-IMIDAZOLE 1-Boc-3-(Amino)azetidine 1-[4-(BROMOMETHYL)PHENYL]-1H-PYRAZOLE 5-Bromoindazole N-(3-Aminopropyl)-imidazole 4-Chloroimidazole 1-Phenylimidazole ?????? 1-[(4-Methylphenyl)sulfonyl]-1H-imidazole 6-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID ???? Oxiconazole nitrate 1-BENZYL-2-IMIDAZOLECARBOXYLIC ACID 2-CYANOPYRIDINE-4-CARBOXALDEHYDE 4-(1H-IMIDAZOL-1-YL)BENZOIC ACID ??????? Detergent,industrial chloroalcohol type homogeneous strongly basic anion exchange membrane 4-(HYDROXYMETHYL)PICOLINITRILE (S)-4-BOC-MORPHOLINE-3-CARBOXYLIC ACID 1-METHYL-5-NITROIMIDAZOLE ???? 4-(1H-????-1-?)?????? 4-Nitroimidazole Sisthsne ????? 2-Imidazol-1-ylethanamine Econazole 5-(AMINOMETHYL)-1-METHYLPYRROLIDIN-2-ONE

???? ?? ??

???( 862)?? ??

???	??	???	??	?? ?	??
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???? ?? ??:

??????? ???? 1,1′-???????? 1H-?????? IMIDAZOLE-15N2 Sorafenib IMpurity Phenol, 4-(hydroxyamino)- Methyl 4-chloropicolinate 2-Chloro-5-nitrobenzotrifluoride Sorafenib β-D-Glucuronide 2-Pyridinecarboxamide,N-methyl-(9CI) Sorafenib Related Compound 22 Sorafenib-d3 4-(2-Aminophenoxy)-N-methylpicolinamide IFLAB-BB F2108-0089 3-(Trifluoromethyl)phenyl isocyanate Sorafenib Related Compound B 4-HYDROXYPHENYLFORMAMIDE